Steroid Hormone Action

Plasma steroid-binding proteins: primary gatekeepers of steroid hormone action

Biologically active steroids are transported in the blood by albumin, sex hormone-binding globulin (SHBG), and corticosteroid-binding globulin (CBG). These plasma proteins also regulate the non-protein-bound or 'free' fractions of circulating steroid hormones that are considered to be biologically active; as such, they can be viewed as the 'primary gatekeepers of steroid action'. Albumin binds ...

Molecular Endocrinology and Steroid Hormone Action

potential application of the recent discoveries. For example, decreased expression of adhesion molecules may be a mechanism by which tumor cells escape immune surveillance. New therapeutic modalities are discussed, such as CD4 immunoadhesins for passive AIDS immunotherapy, and a urokinase-antifibrin conjugate that increases the fibrinolytic potency of urokinase. A particularly interesting chapt...

Steroid hormone action in eucaryotic cells.

Molecular mechanisms of steroid hormone action.

Steroid hormone receptor expression and action in bone.

The skeleton is a complex tissue, and hormonal control of bone remodelling is elaborate. The important role that steroid hormones play in bone cell development and in the maintenance of normal bone architecture is well established, but it is only relatively recently that it has become possible to describe their precise mechanism of action. This review focuses not only on the steroid hormones (o...